Heated High Flow Nasal Cannula – Elevated Mean Airway Pressure?

Can the use of Heated High Flow Nasal Cannula (HHFNC) at a high percentage of nare occlusion result in dangerously elevated mean airway pressure (MAP)?

Gerald Moody studied this using the ASL 5000 Breathing Simulator and found that occlusion of nares by nasal cannula greatly influences MAP and significant pressures can be generated when occlusion is greater than 75%.  Learn more.