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The ASL 5000 can be effectively used in aerosol delivery
testing experimental setups where a single
breath application is used to obtain a
sample from a drug delivery device to be
analyzed in a multi-stage impactor or other
device for determining particle size
distribution.
The Auxiliary Gas Exchange Cylinder (AGEC) accessory (Part
no. 31 00 600) is designed to be used for
this purpose together with two one-way
valves configured as a T-piece. The AGEC
acts as a “bag-in bottle” device where the
simulator is removed form the delivered drug
and possible contamination.
Figures one and two illustrate gas flow during a simulated
inspiration/expiration cycle. (Just one
breath programmed for the simulator).
Inspiration can be chosen to represent a
patient's actual breath flow pattern, while
expiration can be programmed to occur at the
rate of flow required by the impactor or
particle sizing device (for example: 28.3
L/min).
During the inspiration, flow will reach the bag in the AGEC
from the drug delivery device based on the
inspiratory movement of the simulator
piston. The area around the bag inside the
AGEC (see Fig. 1) will start to be
evacuated, thus inflating the bag. The
inspiration should be shaped to reflect
actual patient behavior when using the drug
delivery device.
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